Recommended Daily Dosage:
Adults: Take 1 capsule twice daily or as directed by a Health Care Practitioner.
Children: Not recommended for children.
Application notes: Very occasionally, adverse
effects have been reported after ingestion of either fresh broccoli sprouts or supplements manufactured from fresh sprouts. These effects
are typically gastrointestinal in nature and may include nausea, bloating, gastro-abdominal discomfort, and diarrhoea. The skin as an organ of elimination may also be temporarily impacted, together with
neural function which is sensitive to redox-nflammation imbalances. The limited data available seem to indicate that gastro-intestinal effects
are generally limited to those with pre-existing conditions and in particular to those with dysbiosis associated with a perturbed gut ecosystem.
Dose Titration: In sensitive individuals
experiencing any of the aforementioned concerns, titration up to a full dose from a low starting dose allows progressive correction of the
underlying causes without overloading the patient’s ability to adapt. The goal is to enable the patient to tolerate the full sulforaphane dose at a pace that eliminates symptoms whilst simultaneously restoring
homeostasis.
Instructions for Dose Titration:
1. Discontinue all source of SFN – cruciferous vegetables, broccoli sprout powder and/or capsules.
2. Assuming symptoms abate, resume SFN at a very small dose. This dose may be as little as will fit on the tip of a sharp vegetable knife blade. EnduraCell® powder is the best option, although capsules can be
opened.
3. Take this dose daily for a few days to ensure that the gastrointestinal system feels comfortable.
4. Gradually increase the dose by taking a second similar dose each day.
5. Repeat the process by increasing a little each day, monitoring symptoms to determine daily dose.
6. Typically, within 2 weeks, the standard recommended dose will not produce significant ill effects. In severe cases, tolerance may take
weeks more to achieve. Be guided by the patient’s response.
7. Those with known dysbiosis or other gastrointestinal issues will typically find that these symptoms have either partially or fully cleared. Cruciferous vegetables can be re-introduced at this stage.
8. Where a patient has been intolerant to other foods, their introduction can be trialled one at a time.
Store below 30°C
Direct-acting antioxidants
When mega-doses of direct-acting antioxidants are consumed, the cell may become saturated, masking the pro-oxidant signals the cell needs to defend itself via Nrf2. Unless there is deficiency, vitamin C and any
other direct-acting antioxidant supplements like A, E, beta-carotene & NAC, will inhibit the cell’s ability to upregulate its own antioxidant, detoxification and other cytoprotective genes. If needed at all, antioxidant supplements should be reduced to quantities no greater than RDI levels
found in a plant rich diet.
Cancer and treatments
Chemotherapy and Radiation: Because cancer cells ‘hijack’ the cell’s defence mechanisms, it is unknown whether SFN, GliSODin or other protective plant molecules in normal cells might also increase a cancer
cell’s ability to protect itself. It is therefore advisable to avoid prescribing SFN, GliSODin and other concentrated plant extracts in those diagnosed with cancer – or undergoing treatments such as chemotherapy and radiation.
Anti-coagulant medications
The RDI for Vitamin K1 is 700 mcg. A mature broccoli vegetable contains 85 mcg of Vit K1. The Vitamin K1 content of broccoli sprouts is low in comparison, with one 700 mg capsule of EnduraCell® BioActive containing approximately 7 mcg of Vitamin K1. While Vitamin K2 appears not to interfere with coagulation, it is recommended that the patient’s clinician be consulted to prescription of GFC.
Goitrogens and thyroid function
Broccoli sprouts do not contain any significant goitrogens as found in the mature broccoli vegetable, so there are no contraindications to prescribing Cell-Logic’s broccoli sprout formulae in thyroid conditions.
